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  1. Main
  2. Employees
  3. Hayarpi Mantash Simonyan
download PDF
34-11
(060) 71-04-11
hayarpi.simonyan@ysu.am
Hayarpi
Mantash
Simonyan
Institute of Pharmacy
Chair of Pharmaceutical Chemistry and Pharmacognosy
Head of the chair, associate professor

Personal information

Date of birth
1983
Scientific interests
  • Asymmetric synthesis of non protein amino acids
Education
Institution
Yerevan State University
Faculty
Faculty of Chemistry
Date
2001 - 2006
Degree name
Qualified specialist
Scientific Rank/degree
Institution
Yerevan State University
Date
2014
Degree name
Candidate
Specialty
Chemical sciences
Scientific Supervisor
Ashot Saghyan
Research Topic
Biomimetic asymmetric synthesis of new heterocyclic substituted non-proteinogenic α-amino acids
Language skills
English
Русский
Work experience
Institution
EU4INNOVATION project, World Bank Armenia
Period of time
2019 - 2022
Rank/degree
Chemistry Expert
Institution
YSU Institute of Pharmacy, Chair of Pharmaceutical Chemistry and Pharmacognosy
Period of time
2017 till now
Rank/degree
Head of the Chair
Institution
Araratian Baccalaureate Examination Center
Period of time
2016 - 2018
Rank/degree
Chemistry subject specialist,
Institution
YSU Institute of Pharmacy
Period of time
2014 - 2017
Rank/degree
Assistant professor
Institution
YSU Institute of Pharmacy
Period of time
2014 till now
Rank/degree
Senior researcher
Institution
Scientific and Production Center “Armbiotechnology” NAS RA
Period of time
2007 - 2019
Rank/degree
Junior Researcher
Institution
YSU Faculty of Chemistry
Period of time
2006 - 2014
Rank/degree
Junior Researcher
Participation in international conferences and seminars
22/07/2022 - 03/08/2022
Scientific Collaboration
Institute of Biostructures and Bioimaging (IBB) of the National Research Council (CNR)
Italy
18/02/2020 - 21/02/2020
Discussion of joint educational programs
Peoples' Friendship University of Russia, Belgorod State National Research University of RF
Russian Federation (the)
01/09/2019 - 05/09/2019
VIII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry
Athens
Greece
08/07/2018 - 13/07/2018
16th Belgian Organic Synthesis Symposium
Brusseles
Belgium
24/07/2017 - 26/07/2017
5th International Conference of Green chemistry and Technology
Rome
Italy
03/08/2015 - 07/08/2015
14th International Congress on Amino Acids, Peptides and Proteins
Vienna
Austria
29/07/2014 - 31/07/2014
International Congress on Green Chemistry and Sustainable Engineering
Barcelona
Spain
09/10/2013 - 13/10/2013
11th International Congress of Young Chemists
Poznan
Poland
17/09/2013 - 21/09/2013
3th International Scientific Conference "New trends in the chemistry of heterocyclic compounds",
Pyatigorsk
Russian Federation (the)
17/05/2013 - 19/05/2013
3-rd International Conference of Young Scientists
Tbilisi
Georgia
12/11/2012 - 16/11/2012
6th International conference “Chemistry of Nitrogen Containing Heterocycles”
Kharkov
Ukraine
21/04/2012 - 23/04/2012
Second International Conference of Young Chemists
Tbilisi
Georgia
Membership
Institution
Member of the Association of Young Chemists
Period of time
2013 - 2023
Institution
Member of RA "Armenian Association of Biotechnologists" public organization
Period of time
2014 - 2023
Institution
Member of the Scientific Council of YSU Institute of Pharmacy
Period of time
2015 - 2023
State awards and honorary titles
2015
State prize in the field of exact and natural sciences for the work "Efficient small-scale production technology of new generation non-protein amino acids"

Publications

- Կատեգորիա -
Article
Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery
Hayarpi Simonyan
Satenik Petrosyan
Lusine Sahakyan
Gagik Melikyan
Ashot Sagyan
Rosanna Palumbo
Caterina Vicidomini
Pasqualina Liana Scognamiglio
Giovanni N. Roviello
Molecular Therapy Nucleic Acids
2025
102478
Article
Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer’s Disease
Tatevik Sargsyan
Hayarpi Simonyan
Avetis Tsaturyan
Lala Stepanyan
Raffaele Pastore
Caterina Vicidomini
Germano Guerra
Giovanni N. Roviello
Biomolecules
2025
452
Article
BSA Binding and Aggregate Formation of a Synthetic Amino Acid with Potential for Promoting Fibroblast Proliferation: An In Silico, CD Spectroscopic, DLS, and Cellular Study
Hayarpi Simonyan
Rosanna Palumbo
Satenik Petrosyan
Anna Mkrtchyan
Armen Galstyan
Ashot Saghyan
Pasqualina Liana Scognamiglio
Caterina Vicidomini
Marta Fik-Jaskólka
Giovanni N. Roviello
Biomolecules
2024
579
Article
Advances in Amino Acid-Based Chemistry
Hayarpi Simonyan
Rosanna Palumbo
Giovanni N.Roviello
Pharmaceuticals
2023
1490
Article
Asymmetric Synthesis of Derivatives of Alanine via Michael Addition Reaction and their Biological Study
Mkrtchyan Anna
Tovmasyan Anna
Paloyan Ani
Sargsyan Armen
Simonyan Hayarpi
Sahakyan Lusine
Petrosyan Satenik
Hayriyan Liana
Sargsyan Tatevik
Synlett
2022
2013-2018
Article
Spectroscopic and SEM evidences for G4-DNA binding by a synthetic alkyne-containing amino acid with anticancer activity
Marta A.Fik-Jaskółka
Anna F.Mkrtchyan
Ashot S.Saghyan
Rosanna Palumbo
Agnieszka Belter
Liana A.Hayriyan
Hayarpi Simonyan
ValentinaRoviello
Giovanni N.Roviello
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
2020
117884
Article
Biological macromolecule binding and anticancer activity of synthetic alkyne-containing L-phenylalanine derivatives
Marta A. Fik-Jaskółka
Anna F. Mkrtchyan
Ashot S. Saghyan
Rosanna Palumbo
Agnieszka Belter
Liana A. Hayriyan
Hayarpi Simonyan
Valentina Roviello
Giovanni N. Roviello
Amino Acids
2020
755–769
Article
Исследование асимметрического нуклеофильного бис-присоеденения дегидроаланиновых комплексов Ni(II)
Петросян С. Г.
Симонян А. М
Мкртчян А. Ф.
Саакян Л. Ю.
Цатурян A. O.
Сагян А. С.
Հայաստանի քիմիական հանդես
2020
213-222
Manual
Ամինաթթուների ֆիզիկաքիմիական, օպտիկական հատկությունները և ստացման եղանակները
Հ.Մ. Սիմոնյան
Ա.Ֆ. Մկրտչյան
2018
40
Manual
ՊԵՊՏԻԴՆԵՐ, ՖԵՐՄԵՆՏՆԵՐ
Ա. Ֆ. Մկրտչյան
Հ․Մ․ Սիմոնյան
2018
36
Article
Synthesis and biological evaluation of a novel Amadori compound
Hayarpi Simonyan
Giovanni N. Roviello
Roberta Iannitti
Valentina Roviello
Rosanna Palumbo
Caterina Vicidomini
Amino Acids
2017
327-335
http://link.springer.com/journal/726
Article
Асимметрический синтез новых гетероциклически замещенных аналогов α-аминомасляной кислоты, содержащих замещенные триазольные группы в боковом радикале
А.С.Сагиян
Л.Ю.Саакян
А.М.Симонян
С.Г.Петросян
А.Ф.Мкртчян
М.А.Самвелян
Т.В.Кочикян
П,Лангер
Химический Журнал Армении
2017
71-81
http://www.flib.sci.am/eng/Qimia/Frame.html
Article
Асимметрический синтез новых гетероциклически замещенных аналогов (S)-α-аланина, содержащих 3,4-дизамещенные -5-тиоксо-1,2,4-триазолы в боковом радикале
А.М.Симонян
А.С.Сагиян
Л.Ю.Саакян
Н.Н.Багян
А.О.Восканян
Ж.Н.Сарибекян
М.А.Самвелян
Т.В.Кочикян
Химический Журнал Армении
2017
82-91
http://www.flib.sci.am/eng/Qimia/Frame.html
Article
Lac-L-TTA, a novel lactose-based amino acid–sugar conjugate for anti-metastatic applications
Hayarpi Simonyan
Giovanni N. Roviello
Roberta Iannitti
Rosanna Palumbo
Caterina Vicidomini
Valentina Roviello
Amino Acids
2017
1347-1353
http://link.springer.com/journal/726
Article
Асимметрический синтез (S)-b-(4-(b-фенэтил)-3-бутил-5-тиоксо-1,2,4-триазол-1-ил)-α-аланина
А.М. Симонян
Հայաստանի քիմիական հանդես
2017
522-528.
Article
ВЫДЕЛЕНИЕ ПРОЛИНА ИЗ СМЕСИ АМИНОКИСЛОТ
А.М. Симoнян
А.С. Сагян
Ж.Н. Сарибекян
А.Е. Агаджанян
Հայաստանի քիմիական հանդես
2017
417-429
Article
New generations of optically active non-proteinogenic α-amino acids, synthesis and study
Hovhannisyan A. M.
Saghyan A. S.
Mkrtchyan A. F.
Simonyan H. M
Հայաստանի քիմիական հանդես
2016
81-101
http://www.flib.sci.am/eng/Qimia/Frame.html
Article
Synthesis of enantiomerically enriched amino acids containing acetylenic bond in the side-chain radical
Hayarpi M. Simonyan
Ashot. S. Saghyan
Anna F. Mkrtchyan
Ani J. Karapetyan
Zorayr Z. Mardiyan
Liana A. Hayriyan
International Journal of Chemical Engineering and Applications
2016
413-416
http://www.ijcea.org/
Article
Синтез положительно заряженных комплексов CoIII и их исследование в качестве хиральных катализаторов в реакциях асимметрического генерирования C-C связи.
Мкртчян А. Ф.
Геолчанян А. В.
Симонян А. М.
Петросян С. Г.
Сагиян А. С.
Малеев В. И.
Белоконь Ю. Н.
Хрусталев В. Н
Химический Журнал Армении
2015
108-121
http://www.flib.sci.am/eng/Qimia/Frame.html
Article
АСИММЕТРИЧЕСКИЙ СИНТЕЗ НОВЫХ ЭНАНТИОМЕРНО ОБОГАЩЕННЫХ НЕНАСЫЩЕННЫХ α-АМИНОКИСЛОТ
А. Ф. МКРТЧЯН
З. З. МАРДИЯН
А. Ж. КАРАПЕТЯН
А. С. ПОГОСЯН
С. Г. ПЕТРОСЯН
А. М. СИМОНЯН
А. О. ЦАТУРЯН
А. С. САГИЯН
Химический Журнал Армении
2015
403-412
http://www.flib.sci.am/eng/Qimia/Frame.html

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